How is abacavir made?

How is abacavir made?

Similar to other nucleoside analog reverse-transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications, and is not recommended by itself….Abacavir.

What is the mechanism of action of abacavir?

Mechanism of Action: Nucleoside Analog Reverse Transcriptase Inhibitor (NRTI) Abacavir is intracellularly phosphorylated to carbovir triphosphate, which is incorporated into the HIV DNA during reverse transcription. Carbovir triphosphate lacks a 3′-OH group and thus results in chain termination.

What is the purpose of abacavir?

Abacavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Abacavir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood.

What is the chemical name for abacavir?

The chemical name of abacavir sulfate is (1S,cis)-4-[2-amino-6- (cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate (salt) (2:1).

Who manufactures abacavir?

ViiV Healthcare receives FDA approval for Triumeq® (abacavir, dolutegravir and lamivudine), a new single-pill regimen for the treatment of HIV-1 infection | GSK.

How is abacavir metabolized?

Abacavir is primarily metabolized via two pathways, uridine diphosphate glucuronyltransferase and alcohol dehydrogenase, resulting in the inactive glucuronide metabolite (361W94, ~36% of the dose recovered in the urine) and the inactive carboxylate metabolite (2269W93, approximately 30% of the dose recovered in the …

What gene metabolizes abacavir?

Initially, abacavir is metabolized to abacavir 5′-monophosphate by the enzyme adenosine phosphotransferase (encoded by the ADK gene).

Who takes abacavir?

Abacavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 months of age and older. Abacavir is always used in combination with other HIV medicines.

What is abacavir sulfate?

A sulfate salt form of abacavir, a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. US brand name: Ziagen.

Who created Triumeq?

The drug is developed and manufactured by ViiV Healthcare, a company headquartered in the UK. Triumeq received marketing authorisation from European Commission (EC) for the treatment of HIV in adults and adolescents aged 12 years and older, and weighing at least 40kg, in September 2014.

Is ViiV publicly traded?

In 2012 Shionogi joined the company. 76.5% of the company is now owned by GlaxoSmithKline, 13.5% by Pfizer and 10% by Shionogi….ViiV Healthcare.

Abacavir is a Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of abacavir is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of abacavir is Nucleoside Analog.

Is abacavir a nucleoside?

Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5′-triphosphate (dGTP).

What is ababacavir (ABC)?

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring.

How is abacavir converted into carbovir triphosphate?

Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5′-triphosphate ( dGTP ). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.