What happens when NF-kB is activated?
NF-κB target genes involved in inflammation development and progression. NF-κB is an inducible transcription factor. After its activation, it can activate transcription of various genes and thereby regulate inflammation.
What genes does NF-kB regulate?
NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells.
Is NF KB a protein?
NF-κB (or NF-kappaB, “nuclear factor kappa-light-chain-enhancer of activated B cells”) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
Where does NF-κB bind to target cells?
NF-κB binding is found at several sites in the locus, particularly upstream of the IGLV1 and IGLV3 clusters (Table 3). Taken together, these data indicate that NF-κB binding occurs at a large number of target sites including those that may be functionally significant in other cell types or under different conditions.
How do you find the binding sites of P65?
The binding sites of the NF-κB family member p65 were determined by using chromatin immunoprecipitation and a genomic microarray of human chromosome 22 DNA. Sites of binding were observed along the entire chromosome in both coding and noncoding regions, with an enrichment at the 5′ end of genes.
What is the function of NF-κB transcription factors?
The NF-κB family of transcription factors plays an essential role in regulating the induction of genes involved in several physiological processes, including apoptosis, immunity, and inflammation.
Where do transcription factor binding sites occur?
Sites of binding were observed along the entire chromosome in both coding and noncoding regions, with an enrichment at the 5′ end of genes. Strikingly, a significant proportion of binding was seen in intronic regions, demonstrating that transcription factor binding is not restricted to promoter regions.
